Tetanus immunoglobulin


Generic Medicine Info
Indications and Dosage
Intramuscular
Passive immunisation against tetanus
Adult: For the postexposure prophylaxis of patients with tetanus-prone injuries, those who are unimmunised or inadequately vaccinated against tetanus, whose tetanus immunisation history is unknown or uncertain, whose last dose of tetanus vaccine has elapsed for >10 years, or with impaired immunity: In conjunction with a tetanus toxoid-containing vaccine (refer to specific country guideline): 250 international units via deep IM inj. If >24 hours have passed since injury, if the patient is at risk of heavy contamination, or after burns: 500 international units as a single dose via deep IM inj. Administer large volumes (>5 mL) in divided doses at different sites.
Child: Same as adult dose. Administer large volumes (>2 mL) in divided doses at different sites.

Intramuscular
Tetanus
Adult: For the treatment of cases in combination with anti-infective agents, sedatives, and muscle relaxants: 3,000-6,000 international units via deep IM inj. Dosing frequency, interval of administration, and duration of treatment may vary among countries and individual products (refer to country-specific guidelines).
Child: There is limited information regarding the use of this drug in this population, treatment recommendations may vary among countries and individual products (refer to country-specific guidelines).
Contraindications
Hypersensitivity.
Special Precautions
Patient with immunoglobulin A deficiency, risk factors for thrombotic events (e.g. history of vascular disease or thrombotic events, acquired or inherited thrombophilia, prolonged periods of immobilisation, diseases that increase blood viscosity, severe hypovolaemia, hypertension, and diabetes mellitus). Children. Pregnancy and lactation.
Adverse Reactions
Significant: Immunoglobulin A antibody development, hypersensitivity reaction, shock, arterial and venous thromboembolic events (e.g. MI, stroke, DVT, pulmonary embolism). Rarely, hypotension.
Cardiac disorders: Tachycardia.
Gastrointestinal disorders: Nausea, vomiting, glossitis, buccal ulceration.
General disorders and administration site conditions: Fever, malaise, chills, chest pain, inj site reactions.
Musculoskeletal and connective tissue disorders: Arthralgia, moderate back pain.
Nervous system disorders: Headache, dizziness, tremor.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Skin and subcutaneous tissue disorders: Erythema, pruritus, facial oedema.
IM/Parenteral: C
Monitoring Parameters
Assess for signs and symptoms of thromboembolic events (e.g. shortness of breath, pain and swelling of the limbs, focal neurological deficits, chest pain).
Drug Interactions
May decrease the therapeutic efficacy of live vaccines (e.g. measles, rubella, mumps, varicella).
Lab Interference
May interfere with certain serological tests. May cause a false positive result for red cell alloantibodies (e.g. Coomb's test) and skin tests.
Action
Description:
Mechanism of Action: Tetanus immunoglobulin is a hyperimmune globulin with a specifically high content of antibodies that neutralise tetanus toxins produced by Clostridium tetani which allows passive immunity to tetanus.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: Approx 2 days.
Excretion: Half-life elimination: Approx 3-4 weeks.
Storage
Store between 2-8°C. Do not freeze. Protect from light.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J06BB02 - tetanus immunoglobulin ; Belongs to the class of specific immunoglobulins. Used in passive immunizations.
References
Anon. Tetanus Immune Globulin (Human). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/10/2023.

Anon. Tetanus Immune Globulin. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 12/10/2023.

Buckingham R (ed). Tetanus Immunoglobulins. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/10/2023.

CSL Behring (NZ) Ltd. Tetanus Immunoglobulin VF 250 International Units, Solution for Intramuscular Injection data sheet 8 June 2022. Medsafe. http://www.medsafe.govt.nz. Accessed 12/10/2023.

Human Tetanus Immunoglobulin 100 International Units/mL Solution for Injection (Bio Products Laboratory Limited). MHRA. https://products.mhra.gov.uk. Accessed 12/10/2023.

Hypertet Injection (Grifols USA, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 12/10/2023.

Joint Formulary Committee. Tetanus Immunoglobulin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/10/2023.

Tetagam P Solution for Injection (CSL Behring). MIMS Philippines. http://www.mims.com/philippines. Accessed 12/10/2023.

Disclaimer: This information is independently developed by MIMS based on Tetanus immunoglobulin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
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